Combination Effect of Eannatto δ-Tocotrienol and γ-Tocopherol on Prostate Cancer Cell Growth produced Surprising Results!

Investigating the anti-cancer activities of the Delta-Tocotrienols and Gamma-Tocopherols on Prostate cancer cells in combination.
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human prostate cancer cells, kindly refer to the reference link provided at the bottom of this abstract.
TOCOTRIENOLS CAN SUPPORT

INDUCTION OF APOPTOSIS IN PROSTATE CANCER CELLS

CELL CYCLE ARREST IN THE G1 AND G2/M PHASE

CELL CYCLE ARREST IN THE G1 AND G2/M PHASE
Introduction to Prostate Cancer and TRF
Prostate cancers are caused when the cells of the prostate gland start to multiply uncontrollably. Prostate cancer is the 2nd leading cause of cancer-related deaths in the United States. In this study, a combination of Delta-Tocotrienols, and Gamma-Tocopherols was investigated for their anticancer properties against prostate cancer cells. Hence, in this study it has been investigated if the combination of both the isomers strengthens the inhibitory effects Delta-Tocotrienols on prostate cancer cell growth.
How does Delta-Tocotrienol fight Prostate Cancer?
In this study, the activities of Annatto Delta-Tocotrienols and Gamma-Tocopherol were investigated against the human androgen-dependent prostate cancer cells (LNCaP). It was observed that the combined treatment of Gamma-Tocopherol and Delta-Tocotrienol resulted in reinforced anti-prostate cancer mechanisms and activities. The combination of both the isomers induced G1 arrest as well as G2/M arrest. The combined treatment also resulted in enhanced induction of apoptosis or programmed cell death in the prostate cancer cells. Hence, it can be concluded from the study that the combination of Gamma-Tocopherol and Delta-Tocotrienol incredibly inhibits the growth of prostate cancer cells due to the simultaneous cell cycle arrest in the G1 as well as the G2/m phase. To conclude, Tocotrienols have been observed to have high potential in the prevention and treatment of prostate cancer. In vitro studies have shown that Gamma-Tocotrienols promotes apoptosis and autophagy in human prostate cancer cells. Moreover, Tocotrienol rich fraction (TRF) has also displayed chemopreventive and therapeutic activities against prostate cancer cells by inducing cell cycle arrest and apoptosis.
Suggested Usage:

Eannatto DeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-900mg of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.
Reference for the Study in detail:

1. https://pubmed.ncbi.nlm.nih.gov/29225320/

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600692/

3. https://www.cancer.org/cancer/prostate-cancer/about/what-is-prostate-cancer.html

4. https://www.cancer.net/cancer-types/prostate-cancer/statistics

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