Originally, Herbert McLean Evans was the one who figured out how pivotal Vitamin E is, to avoid birth deficiencies, but it took till late 1950’s that scientists became conscious about the family of Vitamin E, that has two main subgroups known as tocopherols and tocotrienols, that further divides into four molecules which are different physically and chemically known as [alpha, beta, Gama, delta) four tocopherols and four tocotrienols.
Vitamin E particles look quite akin but distinctions in their molecular arrangement make a difference. Statistically, vitamin E molecules have a ‘head’ and a ‘tail’. If we talk about the vitamin E subfamilies, antioxidant activities take place in chromanol head. As every vitamin E molecule has a chromanol head, all of them are antioxidants, though their influence differs. The figure of the head decides if the Vitamin E molecule is Alpha, Beta, Gamma or Delta. Generally, Gamma and Delta have minor heads and they have enhanced contact with the cell membranes. They have the potency to patch the damage speedily. Therefore, they have a high capacity to deliver the aids. To determine, if a vitamin E molecule belongs to the tocopherol or tocotrienol subfamily of vitamin E, length of the molecule’s tail is considered. Tocotrienols come with short tails with double bonds which delivers a supple and flexible way to embrace large surface areas of the membrane. On the other hand, tocopherols have a longer tail without any double bonds (phytyl), that grounds them to be static, and subsequently, they shield a more restrained surface area of the cell membrane. The vitamin E subfamily has also shown its benefits by curbing down the cholesterols, maintenance of cardiovascular and metabolic health and curing cancer. It is also quite evident that tocotrienols perform 50x greater antioxidants potential than tocopherols.
It even astounded the scientists when Annato was discovered as a chief source of tocotrienols. The supremely effective delta and Gamma-tocotrienol are delivered by the plant naturally which is tocopherol-free and the composition is quite unusual.
Sometimes, tocopherols intervene with tocotrienols benefits. It was observed in 1996 that the cholesterol curbing properties of tocotrienol were intervened by its own family element-alpha tocopherol. It was stated by the scientists and researchers that ideally, effective tocotrienol preparations ought to comprise of less than 15 % of alpha-tocopherol and more than 60% of desmethyl tocotrienols (Gamma and Delta tocotrienols) and here comes the best part about our product, overlapping all the challenges that we get by the intervention of tocopherol in tocotrienols, Annato serves you the most natural form of tocotrienols. It guarantees you the best and the purest formula of most effective delta and gamma tocotrienols(90% and 10 % respectively).
The replacement of methyl groups on the chromanol head of the tocotrienol molecule has a significant part when it comes to the efficacy. Tocotrienol isomers (along with the tocopherol isomers) have been labeled on the chromanol head by the substitution of methyl groups. We get alpha-tocotrienol, if the chromanol head contains three methyl substitutes(trimethylated) at position c-5, -7 and -8 and if we substitute it with two methyl groups(dimethylated), it is either beta tocotrienol (substitution at position c-5 and -8)or gamma-tocotrienol(substitution at position c-7 and -8) at position c-8, Delta-tocotrienol has merely one methyl group(monomethylated). Generally, less methylated tocotrienols are way dynamic than fully methylated tocotrienols and it performs best when c-5 is left unoccupied. According to the latest studies, delta and gamma tocotrienol, which we have known as “desmethyl tocotrienols” (des T3) are supremely effective in its results. This happens majorly because of the absence of the stearic intervention with less methylated tocotrienols which lets them enter into the mutilated membrane. At the same time, it also stimulates the consumed tocotrienol, more rapidly. To be more precise, desmethyl tocotrienols and delta-tocotrienols have a propensity to act and cure damaged membranes promptly.
As per the scientific researches, until 2003, only palm and rice were supposed to be the marketable and major sources of natural tocotrienol. Both of the sources used to have a substantial quantity of alpha-tocopherol, which was produced to intervene with the tocotrienol benefits. Tocotrienol-rich fraction (TRF) collectively called for”Palm tocotrienol” and rice tocotrienol”, which is the foundation element or the concoction of tocopherol and tocotrienol, contains 25-50% of tocopherol (majorly as alpha-tocopherol). Besides, Annotto is the natural source of the most effective delta and gamma-tocotrienol, as it is tocopherol-free, which is definitely a rare composition.
On a “medicine man” fact-finding excursion to South America in the late ’90s, Dr. Barrie Tan, who was the founder of American River Nutrition tripped upon the Annatto plant, and he was astounded by the uniquely crimson colored of the plant’s pod and seeds. The plant was known as Bixa Orellana by the Spanish discoverer Francisco de Orellana in the 150’s. He was the one who was introduced to the United States as a food colorant almost 150 years back. It was discovered that the annatto pods were phototrophic, following the sun. Researchers and scientists of American River Nutrition were intrigued to know what was protecting the carotenoids from oxidation and especially accelerated photo-oxidation, as carotenoids are highly labile in nature. After a deep research, it was found that tocotrienol was protecting carotenoid. Besides, it has been the only recognized source Of tocotrienol which does not have tocopherols. Remarkably, only two prevailing peaks were found: delta tocotrienol at about 90% and gamma tocotrienol about 10%. In the words of Dr. Tan, “Right then, I knew we had stumbled onto the best-in-class tocotrienol that nature makes. To this day, I have never seen a similar composition in any other plant.”
Annatto is packed with naturally effective delta and Gamma-tocotrienol which is absolutely free from tocopherol. It is highly beneficial for your lipid cells and helps in mollifying aggravated health concerns.
When the ORAC value of our tocopherol-free tocotrienol product (DeltaGold) was compared with The tocopherol and mixed tocotrienols by Dr. Boxin Ouin Brunswick Laboratories, it was discovered that DeltaGold’s antioxidant performs way superior to the other compounds that were analyzed so far. Besides, it was discovered by the Ohio State University that lard is protected from oxidation by delta and gamma tocotrienol (as in delta gold) at low levels of just 100ppm. Also, Dr. Lester Packer of the University of California presented that tocotrienol is 40 to 60 times supremely effective as an antioxidant than tocopherol.
Tocotrienols are the fat-soluble elements as they come from the Vitamin E family. They are easily absorbed in the akin manner as generally, fats from the food do. They appear to get deposited in the lipid-rich organs like liver, brain, spleen, lung, kidney, and heart. They get circulated and blend in the blood at nearly 4 hours post ingestion. These are absorbed more easily when taken with fat-rich foods.
Conferring to the medicinal recommendation, one should consume 75-100mg/day as per the ideal measure of tocotrienol for cholesterol and triglyceride reduction. If it is taken to maintain the lipid levels and as an antioxidant, petite doses of 25-50 mg may be taken.
It won’t be wrong if we say that most of the human researches and studies were done with the palm, not only because of the reason that it was categorically effective but because it was the primary viable and commercial source that contained tocotrienols to become obtainable. Though few of the considerable human researched with the palm did not go well, there is a definite cause why they fail. It happened because the amount of alpha-tocopherol was extremely high. In more precise words, tocotrienol holds the accountability for alpha-tocopherol when they are composed together. Annatto serves 90% delta-tocotrienol which has been consistently proven to be most effective. Gamma-tocotrienol follows the same when it comes to the effectiveness on close second, of which annatto comprises 10% weight. The chemical identity of the isomers tend to be the same, wherever tocotrienol isomers are purified (e.g. palm, rice, and annatto). That is scientifically how delta and gamma work. The source (palm, rice, and annatto) should be docile to this fact, not the other way round.
The seeds and the extracted colors of annatto seeds are persistently in great use all over South America right from the time it was discovered by Spanish Francisco De Orellana in 1543, and now it’s been more than 450 years after the discovery that it has been in use by the people. Palm oil has been used by the people all over Southeast Asia for more than 45 years now and henceforth, annatto’s usage has been perceived 10x longer than palm is used. Annatto coloring is used on a larger scale by Brazilians and they have been following the same practice for more than a century with no side-effects at all. A normal individual who weighs 60kgs is referred to as consume 4mg/d. annatto is fundamentally nontoxic and the natural colorant is “exempt from certification”. Safety of annatto is totally based.
Most multivitamins contain alpha-tocopherol, which has been shown to interfere with tocotrienol benefits. However, a tocotrienol supplement can be taken at least 6 hours apart from a multivitamin or tocopherol product to prevent alpha-tocopherol interference.
Annatto tocotrienol is better in the sense that it is tocopherol-free, and hence there is no risk for interference with benefits by alpha-tocopherol. In addition, annatto tocotrienol provides only the most potent delta- and gamma-tocotrienol isomers.
Studies at the Ohio State University showed that alpha-tocotrienol is undoubtedly a brain protectant [38, 39]. These studies, however, focused on glutamate-induce (that is, trauma-induced) stroke injury, a very severe and specific condition. Data on delta-tocotrienol appear to be absent in this area of research. With this said, one has to remember that neurotoxicity goes far beyond trauma-induced stroke injuries. There is an array of chronic neurodegenerative disorders, including Alzheimer’s, Huntington’s, and Parkinson’s disease, as well as familial dysautonomia (FD – a genetic disease that causes dysfunction of the autonomic and sensory nervous system). The latter has been extensively studied with tocotrienols, and gamma- and delta-tocotrienol had the greatest effect on improving the condition by raising cellular levels of IKAP [40, 41]. IKAP is a protein that is largely non-functional in this neurodegenerative disease, resulting in autonomic crises characterized by hypertension, abnormally accelerated heart beat, excessive sweating, and vomiting. Following this original study, children with FD now take daily tocotrienol supplements to reduce symptoms of the disease. In short, the jury is still out as to which tocotrienol isomer is best for neuroprotection. It may be that tocotrienol isomers all work to varying degrees in neuroprotection.
It is believed that tocotrienols, which contain a unique farnesyl moiety, disphosphorate the farnesyl pyrophosphate; the thus-freed farnesol down-regulates 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR), the enzyme responsible for the body’s cholesterol production . Tocotrienols also degrade the protein HMGR, a mechanism of action that was elucidated in the early 1990s [43, 44]. Fifteen years later, this original study carried out by Bristol-Myers Squibb was recently revalidated, where researchers elucidate the biochemical mechanism for the hypocholesterolemic effect of tocotrienols on HMGR . In both earlier and recent studies, only desmethyl tocotrienols (namely, delta- and gamma- isomers) had this effect on HMGR. Tocotrienol was found to act like a sterol, creating a feedback mechanism that causes a decrease of HMGR activity by increase of sterol-sensing, including inhibition of gene transcription, blocking translation of mRNA and accelerating degradation of HMGR protein. However, in the more recent study, tocotrienol’s mechanism of action goes further. Tocotrienol was found to block processing of sterol regulatory element-binding proteins (SREBPs).