Colorectal cancer is one of the leading causes of mortality and morbidity in the world. According to an article of BMRAT, in 2016 itself, around 1,400,000 new cases were registered and 700,000 deaths were caused worldwide by Colorectal Cancer! Although in the pursuit to fight colorectal cancer, several studies have been conducted on Annatto based Tocotrienol(Eannatto) which has been observed to possess anti-cancer activities. One such study, ‘Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by Tocotrienol’ was conducted in which it was observed that it was observed that Tocotrienol inhibited telomerase activity of DLD-1 human colorectal adenocarcinoma cells in time- and dose-dependent manner. Interestingly Delta-Tocotrienol was observed to exhibit the highest inhibitory activity.
Why Tocotrienol and Not Tocopherol?
Tocopherol, the enemy of Tocotrienol: Tocopherol interferes with the functioning of Tocotrienol as it attenuates brain cancer inhibition, inhibits absorption, reduces adipose storage, and compromises cholesterol and triglyceride reduction.
Tocotrienol, the protector of State: Tocotrienol has more mobility than Tocopherol due to its small structure so it can cover a larger area targeting more number of colon cancer cells.
- Tocotrienols: Latest Cancer Research in Vitamin E by Barrie Tan, Ph.D., and Anne M.Trias, MS.
- Tocotrienols: The Promising Analogues of Vitamin Efor Cancer Therapeutics https://doi.org/10.1016/j.phrs.2018.02.017
- Colorectal Cancer in the world: incidence, mortality and risk factors. http://www.bmrat.org/index.php/BMRAT/article/view/372