Eannatto Delta-tocotrienol Incredibly Inhibits the Deadly Non-Small-Cell Lung Cancer Cell Invasion

To investigate the possibility of MMP-9 inhibition as the mechanism underlying the antimetastatic properties of Delta-Tocotrienol on NSCLC cells.
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human lung cancer cells, kindly refer to the reference link provided at the bottom of this abstract.
DELTA-TOCOTRIENOLS CAN SUPPORT


INHIBITION OF CELL PROLIFERATION

ATTENUATION OF TUMOR INVASION AND METASTASIS

INCREASE OF miR-451 EXPRESSIONS

REPRESSED EXPRESSION OF MMP-9 & Upa PROTEINS
Introduction to Lung Cancer and Delta-Tocotrienols
Lung cancer is the leading cause of cancer-related deaths among both women and men. Lung cancer constitutes 25% of all cancer-related deaths. Every year, more people die of lung cancer than that of breast, prostate, and colon cancers combined! The anti-invasive effects of Delta-Tocotrienol and its underlying cellular mechanism in NSCLC had not been fully explored. In this study, the effects of Delta-Tocotrienol on cell invasion, migration, adhesion, aggregation, and proliferation capabilities were investigated using different cell-based assays.
How does Delta-Tocotrienol fight Lung Cancer?
In the study, it was observed that Delta-Tocotrienols inhibited cell invasion, migration, adhesion, aggregation, and proliferation in a concentration-dependent manner. Matrix metalloproteinase (MMP-9) based cell migration and invasion are critical mechanisms in cancer growth and development. Hence, it was also observed that Delta-Tocotrienols reduced MMP-9 activities. The Western blot and real-time PCR analysis data also demonstrated that Delta-Tocotrienol was able to increase miR-451 expressions and was able to downregulate Notch-1 mediated NF-kB, which resulted in the repression of the expression of MMP-9 and uPA proteins. Hence, it was shown that Delta-Tocotrienols attenuated tumor invasion and metastasis. All the data generated in the study suggested that Delta-Tocotrienols may have a very potent therapeutic benefit against non-small-cells lung cancer (NSCLC) metastasis.
Suggested Usage:
Eannatto DeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-900g of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.
References for the study in detail:
1. https://pubmed.ncbi.nlm.nih.gov/30100736/
2. Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF-κB pathways in A549 human lung cancer cells.
3.Delta-Tocotrienol Modulates Glutamine Dependence by Inhibiting ASCT2 and LAT1 Transporters in Non-Small Cell Lung Cancer (NSCLC) Cells: A Metabolomic Approach.
4. Molecular Mechanisms of Action of Tocotrienols in Cancer: Recent Trends and Advancements. Aggarwal V, Kashyap D, Sak K, Tuli HS, Jain A, Chaudhary A, Garg VK, Sethi G, Yerer MB.Int J Mol Sci. 2019 Feb 2;20(3):656. doi: 10.3390/ijms20030656.PMID: 30717416 Free PMC article. Review. 5. S-Adenosylmethionine synergistically enhances the antitumor effect of gemcitabine against pancreatic cancer through JAK2/STAT3 pathway.
6. Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor-independent urokinase-type plasminogen activator inhibition. Oh SH, Lee OH, Schroeder CP, Oh YW, Ke S, Cha HJ, Park RW, Onn A, Herbst RS, Li C, Lee HY.Mol Cancer Ther. 2006 Nov;5(11):2685-95. doi: 10.1158/1535-7163.MCT-06-0142.PMID: 17121915
7. Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-κB, uPA activator and MMP9.
8. Inhibition of invasion, angiogenesis, tumor growth, and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non-small cell lung cancer cells.
9.[Mechanism of tumor cell-induced extracellular matrix degradation–inhibition of cell-surface proteolytic activity might have a therapeutic effect on tumor cell invasion and metastasis].
10. Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin.

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