Gastric Cancer ABHI Gamma Tocotrienol

First Ever Evidence that Eannatto γ-Tocotrienol Inhibits the Growth of Human Gastric Cancer and Chemosensitizes it to Capecitabine
Investigation of Gamma-tocotrienol to be able to sensitize gastric cancer to capecitabine in vitro and a xenograft mouse model.
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human gastric cancer cells, kindly refer to the reference link provided at the bottom of this abstract.
TOCOTRIENOLS CAN SUPPORT

INHIBITION OF PROLIFERATION OF GASTRIC CANCER CELLS

APOPTOTIC EFFECTS OF CAPECITABINE

SUPPRESSION OF TUMOR GROWTH

ANTI-ANGIOGENESIS
Introduction to Gastric Cancer and Delta-Tocotrienols
Gastric cancer or the cancer of the stomach is the 7th most commonly occurring cancer in women and 4th most commonly occurring cancer in men.
Like colorectal cancer, gastric cancer also can develop resistance against chemotherapeutic drugs over time. Also, the poor prognosis of this cancer makes the existing treatment modalities render ineffective. So in this study, a novel agent that is safe and effective, like Gamma-Tocotrienol was investigated, to see if it could sensitize gastric cancer to capecitabine in vitro and a xenograft mouse model.
How does Gamma-Tocotrienol fight Gastric Cancer?
Gamma-Tocotrienol was observed to inhibit the proliferation of gastric cancer cells and promoted the apoptotic effects of capecitabine. The study demonstrated that Gamma-Tocotrienol inhibited the constitutive activation of NF-kB, and suppressed its regulated expression of COX-2, Bcl-2, CXCR4. Cyclin D1, matrix metalloproteinase (MMP-9), and VEGF.
The study also showed, that in the xenograft model of human gastric cancer in nude mice, Gamma-Tocotrienol alone was able to significantly suppress tumor growth. Although, with capecitabine, the effect of Gamma-Tocotrienol on the suppression of tumor growth was even more effective! Gamma-Tocotrienol along with capecitabine downregulated both the proliferation markers, K—67, and CD31.
Suggested Usage:
Eannatto DeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-900g of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.
References for the study in detail:
1. https://pubmed.ncbi.nlm.nih.gov/22351692/
2. https://www.cancer.org/cancer/stomach-cancer/about/key-statistics.html
3. https://pubmed.ncbi.nlm.nih.gov/32183146/
4. Identification of a novel 1,2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells.https://pubmed.ncbi.nlm.nih.gov/32140443/
5. Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone radiant Regel.https://pubmed.ncbi.nlm.nih.gov/32106609/Naz I, et al. Molecules. 2020. PMID: 32106609
6.Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment.https://pubmed.ncbi.nlm.nih.gov/31952197/
7. https://pubmed.ncbi.nlm.nih.gov/31858156/ Khwairakpam AD, et al. J Mol Med (Berl). 2020. PMID: 31858156 Review.
8. S. Bi, J.R. Liu, Y. Li, Q. Wang, H.K. Liu, Y.G. Yan, B.Q. Chen, W.G. Sun, gammaTocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line, Toxicology. 274 (2010) 27-33.
9. H.K. Liu, Q. Wang, Y. Li, W.G. Sun, J.R. Liu, Y.M. Yang, W.L. Xu, X.R. Sun, B.Q. Chen, Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells, J Nutr Biochem. 21 (2010) 206213
10. W. Sun, W. Xu, H. Liu, J. Liu, Q. Wang, J. Zhou, F. Dong, B. Chen, gammaTocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells, J Nutr Biochem. 20 (2009) 276-284.
11. W. Sun, Q. Wang, B. Chen, J. Liu, H. Liu, W. Xu, Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling, Br J Nutr. 99 (2008) 1247-1254.

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