Breast Cancer ABHI TRF

Eannatto Tocotrienols promote Apoptosis in Human Breast Cancer Cells
Anti-cancer activity of Tocotrienol-rich fraction to show cell death in human breast cancer cells.
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human breast cancer cells, kindly refer to the reference link provided at the bottom of this abstract.
TOCOTRIENOLS CAN SUPPORT
ANTI-PROLIFERATIVE EFFECTS IN CANCER CELLS BY INDUCING APOPTOSIS
INCREASE OF SENSITIVITY OF CANCER CELLS TO APOPTOSIS
INVOLVING OF APOPTOTIC CELL DEATH SIGNALING PATHWAY

Introduction to Breast Cancer and TRF

In women, breast cancer is the 2nd most common cause of cancer-related deaths. It has currently become a major challenge to achieve a cure for women with highly aggressive triple-negative breast cancers. Around 15-20% of breast cancer can be classified under the triple-negative type, according to research. At present, most chemotherapeutic treatments aim to accelerate the process of apoptosis, i.e., cell death in cancer cells. TRF is one agent which has been observed to accelerate apoptosis in cancer cells.

How does Tocotrienol-Rich Fraction (TRF) fight Breast Cancer?

It has been observed that Tocotrienols have the ability to induce apoptosis in cancer cells only and not in the normal cells. The researchers have concluded that the selective cell cycle perturbation and apoptosis of Tocotrienols may have been associated with p53 and Akt/NF-kB signaling pathways. Studies have shown the Alpha-Tocopherol does not exhibit any kind of Apoptosis induction or antiproliferative activities in cancers. On the other hand, Delta-Tocotrienol and TRF have been observed to inhibit the proliferation of cancer cells by arresting them in G2 phase, and by inducing apoptosis via expression of Fas ligand, Fas receptor, caspase-8, and caspase-3, in neoplastic mammary epithelial cells. In this study, Tocotrienols were observed to induce anti-proliferation and apoptosis in association with DNA-fragmentation, poly (ADP-ribose) polymerase cleavage, and NF-kB inhibition in the human breast cancer cells
Suggested Usage:
Eannatto DeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 1000mg of dosage of Tocotrienols, have been suggested by researchers for patients suffering from Alzheimer’s Disease. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.
Reference for the Study in detail:
1. https://onlinelibrary.wiley.com/doi/pdf/10.1111/cpr.12014
2. Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int. J. Cancer 94, 153–156.
3. Hisham AN, Yip CH (2004) Overview of breast cancer in Malaysian women: a problem with late diagnosis. Asian J Surg. 27, 130–133.
4. Hisham AN, Yip CH (2003) Spectrum of breast cancer in Malaysian women: overview. World J. Surg. 27, 921–923.
5. Kaufman HL, Wadler S, Antman K (2011) Molecular Targeting in Oncology (Cancer Drug Discovery and Development). Humana Press., Totowa, Nj: 1617376531.
6. Ricci MS, Wei-Xing Z (2006) Chemotherapeutic approaches for
7. targeting cell death pathways. Oncologist 11, 342–357.
8.Fulda S, Gorman Am, Hori O, Samali A (2010) Cellular stress responses: cell survival and cell death. Int. J. Cell Biol. 2010, Article ID 214074, 1–23; doi:10.1155/2010/214074
9. Abdul Hafid SR, Radhakrishnan AK, Nesaretnam K (2010) Tocotrienols are good adjuvants for developing cancer vaccines. Cancer 10 (Article in press) [PMC free article] [PubMed]
10. Balfe P, McCann A, McGoldrick A, McAllister K, Kennedy M, Dervan P, Kerin MJ. Estrogen receptor α and β profiling in human breast cancer. J Cancer Surg. 2004;30:469–474. [PubMed] [Google Scholar]

Leave a Reply

Your email address will not be published. Required fields are marked *

0
Your Cart
Add to cart