Exploring the anti-metastasis mechanisms induced by Gamma-Tocotrienol and its correlation with the invasion and metastatic capacities of gastric adenocarcinoma SGC-7901 cells.
DELTA-TOCOTRIENOLS CAN SUPPORT
INHIBITION OF CELL PROLIFERATION
ATTENUATION OF TUMOR INVASION AND METASTASIS
INCREASE OF miR-451 EXPRESSIONS
REPRESSED EXPRESSION OF MMP-9 &Upa PROTEINS
Vitamin E is a family of two classes of compounds, the Tocotrienols, and the Tocopherols. Before extensive research was carried on Tocotrienols, Tocopherols were believed to be very potent antioxidants but lacked anticancer benefits, but things changed when pure Tocotrienols were discovered in the seeds of the Annatto plant. Tocotrienols. Especially the Delta and Gamma isoforms were observed to have the most potent antioxidant and anticancer abilities!
Introduction to Gastric Cancer and Delta-Tocotrienols
Stomach cancer or gastric cancer is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women. According to data by the American Cancer Society, in the USA, in 2020, there will be around 27,600 new cases of gastric cancer and around 11,010 people will die from gastric cancer.Until the late 1930s, gastric cancer was the leading cause of cancer-related deaths in the US, but it gradually declined due to proper refrigeration of food. A few doctors also believe, that due to the use of antibiotics to cure stomach infections has reduced the cases of gastric cancer. Antibiotics kill a bacterium named, Helicobacter pylori which are believed to cause stomach cancer.
It has been observed that with time, stomach cancer develops resistance against chemotherapeutic drugs. Moreover, the prognosis of this cancer is very poor at the early stages and thus existing treatment modalities turn out to be ineffective with time. Hence, in this study, the inhibitory effects of Gamma-Tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells were examined.
How does Gamma-Tocotrienol fight Gastric Cancer?
It was observed, that at doses of 15, 30,45, and 60 mu mol/L, when given for 48 hours, Gamma-Tocotrienols suppressed cell migration and invasion. Gamma-Tocotrienols was able to significantly reduce the Matrigel invasion capability by downregulating the mRNA expressions of MMP-9 and MMP-2. The Gamma-Tocotrienol induced anti-tumor metastasis activity and demonstrated it’s potential as an effective chemo-preventive agent against gastric cancer.
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