δ-Tocotrienol, a natural form of vitamin E, inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis

Investigating the effects of Delta-Tocotrienol on Pancreatic Ductal Adenocarcinoma
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human breast cancer cells, kindly refer to the reference link provided at the bottom of this abstract.

TOCOTRIENOLS CAN

SHOW SIGNIFICANT ANTICANCER PROPERTIES IN COLON CANCER CELLS
STIMULATE CASPASE-3 AND CASPASE-9 THUS INDUCING APOPTOSIS IN CANCER CELLS
Several research and studies have shown that Tocotrienols, especially the Delta and Gamma isoforms are natural bioactive against cancers as they delay their progression, help kill cancer cells, and suppress the growth of tumors. Delta-Tocotrienols have been observed to be one of the most potent antioxidant, anti-inflammatory, and anticancer agents.

Introduction to Pancreatic Cancer and Delta-Tocotrienol

Pancreatic adenocarcinoma is the most common type of pancreatic cancer and they usually start from the duct of the pancreas. It has been estimated that in the United States of America, in 2020 alone, 24,640 men and 22,410 women will be diagnosed with pancreatic cancer and around 47,050 people will die due to this disease. The worrisome fact regarding this cancer is that it is very difficult to diagnose because this cancer has no symptoms. If found at the early stages, then the tumor can removed and the life expectancy can be increased but since the prognosis isn’t easy, the cancer spreads quite fast and hence, the 5-year survival rate is just 9%. In this study, it has been shown that Delta-Tocotrienol is a natural bioactive against cancer, prevents metastases, and delays progression in transgenic mouse models of Pancreatic ductal adenocarcinoma. The striking feature of this study is that it has given the first evidence of Delta-Tocotrienol inhibits PDAC stem cells!

How does the Redox Derivative Tocotrienol fight Mesothelioma?

In this study, it has been observed that Delta-Tocotrienols prevents metastases and delays progression in transgenic mouse models of pancreatic ductal adenocarcinoma. Also, in this study, the first evidence of Delta-Tocotrienols selectively inhibiting PDAC stem-like cells was demonstrated. It was also observed that Delta-Tocotrienol inhibited the invasion, migration, and several biomarkers of epithelial to mesenchymal transition. Delta-Tocotrienol also suppressed angiogenesis, the process of formation of blood vessels in cancer cells, in the PDAC cells and tumors thus suppressing the tumor growth and the spread of cancer. In an orthotopic xenograft model of human pancreatic ductal adenocarcinoma cells, it was observed that Delta-Tocotrienols incredibly suppressed the growth and metastases of the PDAC human stem-like cells which were even resistant to the anti-cancer drug, gemcitabine! Hence, it can be concluded that, Delta-Tocotrienol can help in chemoprevention of PDAC metastases.
Suggested Usage:

EannattoDeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-1600mg of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer.

Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.

Reference for the Study in detail:
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The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human breast cancer cells, kindly refer to the reference link provided at the bottom of this abstract.

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